Précis of The neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system

  title={Pr{\'e}cis of The neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system},
  author={Jeffrey A. Gray},
  journal={Behavioral and Brain Sciences},
  pages={469 - 484}
  • J. Gray
  • Published 1 September 1982
  • Psychology, Biology
  • Behavioral and Brain Sciences
Abstract A model of the neuropsychology of anxiety is proposed. The model is based in the first instance upon an analysis of the behavioural effects of the antianxiety drugs (benzodiazepines, barbiturates, and alcohol) in animals. From such psychopharmacologi-cal experiments the concept of a “behavioural inhibition system” (BIS) has been developed. This system responds to novel stimuli or to those associated with punishment or nonreward by inhibiting ongoing behaviour and increasing arousal and… 

The septo-hippocampal system and ego

  • R. Pitman
  • Psychology, Biology
    Behavioral and Brain Sciences
  • 1984
It is proposed that these drugs reduce anxiety by impairing the functioning of a widespread neural system including the septo-hippocampal system (SHS), the Papez circuit, the prefrontal cortex, and ascending monoaminergic and cholinergie pathways which innervate these forebrain structures.

Behavioural and neural-system analyses of the actions of anxiolytic drugs

  • J. A. Gray
  • Psychology, Biology
    Pharmacology Biochemistry and Behavior
  • 1988

Animal models of anxiety.

Anxiety, Personality and the Brain

Anxiolytic action on the behavioural inhibition system implies multiple types of arousal contribute to anxiety.

Commentary on '5-HT and mechanisms of defence'

Evidence is drawn to present the case that 5-HT is fundamentally involved in the neural mechanisms of fearmotivated behaviour and, by extension, anxiety, and that5-HT systems mediate resilience, i.e. behavioural adaptation to chronic aversive events.

Beta-carbolines as tools in memory research: animal data and speculations.

From a series of experiments it is concluded that the major reason for benzodiazepine-induced amnesia might be an impaired ability to filter interfering stimuli; that is, an attentional deficit.

The Neuropsychology of Anxiety and Tolerance for Stress

Gray (1982) has developed a general theory of both the psychology of anxiety and the neural structures that mediate this state, and postulates the existence of a ‘behavioural inhibition system’ (BIS) that discharges the information-processing functions of a comparator.

Anxiety and the brain: not by neurochemistry alone

  • J. Gray
  • Biology, Psychology
    Psychological Medicine
  • 1979
The elegant biochemical experiments of Costa's group at NIMH suggest that benzodiazepine receptors are closely associated with (but not identical to) GABA receptors, and the logic of this argument turns GABA itself into a kind of endogenous anti-anxiety agent.

Theories of the dorsal bundle extinction effect

Effect of minor tranquillisers on hippocampal θ rhythm mimicked by depletion of forebrain noradrenaline

It is shown that this kind of frequency-specific effect on septal driving of the hippocampal θ rhythm is also produced by other drugs with similar effects on behaviour, includingethanol, chlordiazepoxide and Δ9-tetrahydro-cannabinol.

The psychophysiological basis of introversion-extraversion.

  • J. Gray
  • Psychology, Biology
    Behaviour research and therapy
  • 1970

The conditioning model of neurosis

  • H. Eysenck
  • Psychology
    Behavioral and Brain Sciences
  • 1979
Abstract The long-term persistence of neurotic symptoms, such as anxiety, poses difficult problems for any psychological theory. An attempt is made to revive the Watson-Mowrer conditioning theory and

The hippocampus and behavioral maturation.