Poxvirus vector-based HIV vaccines.

  title={Poxvirus vector-based HIV vaccines.},
  author={Giuseppe Pantaleo and M Carmen Desco Esteban and Bertram L Jacobs and Jim Tartaglia},
  journal={Current opinion in HIV and AIDS},
  volume={5 5},
PURPOSE OF REVIEW In this review, we will provide the scientific rationale for the use of poxvirus vectors in the field of HIV vaccines, the immunological profile of the vaccine-induced immune responses, an update on the current use of poxvirus vector-based vaccines in HIV vaccine clinical trials, and the development of new modified poxvirus vectors with improved immunological profile. RECENT FINDINGS An Ad5-HIV vaccine was tested in a phase IIb clinical trial (known as the Step trial… CONTINUE READING


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