Poxvirus vaccines for cancer and HIV therapy.

  title={Poxvirus vaccines for cancer and HIV therapy.},
  author={Shaffiq M. Essajee and Howard L. Kaufman},
  journal={Expert opinion on biological therapy},
  volume={4 4},
The poxviridae have a long history of causing disease in society, and their biological effects in humans and other mammals have been extensively studied. In the 1980s, genetic engineering techniques were applied to vaccinia in order to create replicating recombinant vectors that could express inserted genes encoding influenza virus proteins. In animal models, these recombinant viruses were able to deliver their foreign antigens to the immune system and elicit a specific adaptive immune response… CONTINUE READING


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