Powerful placebo: the dark side of the randomised controlled trial

@article{Kaptchuk1998PowerfulPT,
  title={Powerful placebo: the dark side of the randomised controlled trial},
  author={T. Kaptchuk},
  journal={The Lancet},
  year={1998},
  volume={351},
  pages={1722-1725}
}
View on Elsevier
doi.org
313 Citations
Highly Influential Citations
14
Background Citations
98
Methods Citations
14
Results Citations
7

313 Citations

Citation Type

Citation Type

Response to placebo in clinical epilepsy trials—Old ideas and new insights
TLDR
Observations about placebos specific to epilepsy, including the relatively higher placebo response in children, apparent increase in placebo response over the past several decades, geographic variation in placebo effect, relationship to baseline epilepsy characteristics, influence of nocebo on clinical trials, and patterns that placebo responses appear to follow in individual patients are explored. Expand
Evidence-Based Surgery
  • F. Diederich
  • Computer Science
  • Springer International Publishing
  • 2019
TLDR
The evidence based surgery is universally compatible with any devices to read and is available in the digital library an online access to it is set as public so you can download it instantly. Expand
Rethinking placebo in psychiatry: the range of placebo effects †
TLDR
The role of placebo in the pharmacotherapy of depression and complementary and alternative medicine is discussed, and the ‘efficacy paradox’ (that placebo treatments can have larger effects than ‘evidence-based treatments’) is introduced. Expand
Reconsidering the Placebo Response from a Broad Anthropological Perspective
TLDR
It is suggested that the placebo response is an evolutionarily adaptive trait and part of healing mechanisms operating across many levels—from genetic and cellular to social and cultural. Expand
Set and setting, psychedelics and the placebo response: An extra-pharmacological perspective on psychopharmacology
TLDR
This paper examines how placebo theory and set and setting theory can complement and benefit each other, broadening the understanding of how non-biological factors shape response to drugs and other treatment interventions. Expand
Personality and placebo responses in non-pain paradigms: Building a Transactional Model of Placebo Responding
In a modern healthcare environment burdened by symptomatic and mental-health related ailments, the placebo effect may represent a useful clinical tool. However, with the bulk of research to date… Expand
From placebo to self-help : investigating retention, outcome and mechanisms in self-directed gratitude interventions
Above and beyond superstition — western herbal medicine and the decriminalizing of placebo:
Does it work? This question lies at the very heart of the kinds of controversies that have surrounded complementary and alternative medicines (such as herbal medicine) in recent decades. In this ar...
Expectancy effect: Impact of pill administration on cognitive performance in healthy seniors
TLDR
In an exploratory analysis of potential predictors of the expectancy effect, perceived stress and self-efficacy but not personality traits interacted with the pill-taking effect on cognitive function. Expand
Placebo effects: clinical aspects and neurobiology.
  • B. Oken
  • Medicine
  • Brain : a journal of neurology
  • 2008
TLDR
A literature review was performed to retrieve articles discussing placebo implications of clinical trials, the neurobiology of placebo effects and the implications of placebo effect for several disorders of neurological relevance. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 31 REFERENCES
Intentional Ignorance: A History of Blind Assessment and Placebo Controls in Medicine
  • T. Kaptchuk
  • Medicine
  • Bulletin of the history of medicine
  • 1998
La methodologie de la recherche medicale moderne est fondee sur une evaluation en aveugle au cours de laquelle les patients ignorent s'ils sont traites par un placebo ou par un traitement… Expand
Reviews: Medicine and Health-The Progress of Experiment: Science and Therapeutic Reform in the United States, 1900-1990
TLDR
Part I. of Of Institutions and Character: The Era of Organisational Reform: A rational therapeutics, or the Triumph of Method: Managing chance. Expand
Gunver Sophia Kienle: Der sogenannte Placeboeffekt. Illusion, Fakten, Realität. 11 Tab. Schattauer Verlag Stuttgart, New York 1995. DM 34,-
Placebo effect and placebo concept: a critical methodological and conceptual analysis of reports on the magnitude of the placebo effect.
TLDR
The authors conclude that the literature relating to the magnitude and frequency of the placebo effect is unfounded and grossly overrated, if not entirely false, and pose the question whether the existence of the so-called placebos is itself not largely-or indeed totally-illusory. Expand
Variation in the placebo effect in randomised controlled trials of analgesics: all is as blind as it seems
TLDR
The results show that the amount of relief obtained with placebo varies considerably between patients, that 38% of patients obtained more than 10% of the maximum possible relief, and 16% obtained greater than 50%. Expand
Concept of true and perceived placebo effects
TLDR
A review of the literature shows that most authors confuse the perceived placebo effect with thetrue placebo effect, and a distinction between the perceived and the true placebo effects would be helpful in understanding the complex phenomena involved in a placebo response. Expand
Is there logic in the placebo?
Placebo effect in double-blind clinical trials: a review of interactions with medications
Placebo controls and epistemic control in orthodox medicine.
  • M. Sullivan
  • Medicine
  • The Journal of medicine and philosophy
  • 1993
TLDR
The randomized clinical trial (RCT) introduces an epistemic bias into orthodox medicine: therapeutic successes that rely upon a direct link between knowing and healing, such as placebo effects, are discarded in favor of therapeutic successes which rely upon an indirect link betweenKnowing and healing; such as pharmacological interventions. Expand
The 'natural' history of active rheumatoid arthritis over 3-6 months--an analysis of patients enrolled into trials of potential disease-modifying anti-rheumatic drugs, and treated with placebo.
TLDR
ESR is an informative, stable measure of disease activity; the duration of morning stiffness may be more useful than the articular index and there is no measurable placebo effect on ESR, morning stiffness or platelet count when these are used as measures of Disease activity in trials of drug therapy in RA. Expand
...
1
2
3
4
...