Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice.

@article{Pan2010PowerfulBE,
  title={Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice.},
  author={Xiaoli Pan and Neng Gong and Jing Zhao and Zhe Yu and Fenghua Gu and Jia Jie Chen and Xiaojing Sun and Lei Zhao and Meijing Yu and Zhiru Xu and Wenxin Dong and Yan Qin and Guoqiang Fei and Chunjiu Zhong and Tian-le Xu},
  journal={Brain : a journal of neurology},
  year={2010},
  volume={133 Pt 5},
  pages={1342-51}
}
Reduction of glucose metabolism in brain is one of the main features of Alzheimer's disease. Thiamine (vitamin B1)-dependent processes are critical in glucose metabolism and have been found to be impaired in brains from patients with Alzheimer's disease. However, thiamine treatment exerts little beneficial effect in these patients. Here, we tested the… CONTINUE READING