Power output is linearly related to MyHC content in rat skinned myocytes and isolated working hearts.

@article{Korte2005PowerOI,
  title={Power output is linearly related to MyHC content in rat skinned myocytes and isolated working hearts.},
  author={Fredrick S Korte and Todd J. Herron and Michael J. Rovetto and Kerry S McDonald},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={289 2},
  pages={H801-12}
}
The amount of work the heart can perform during ejection is governed by the inherent contractile properties of individual myocytes. One way to alter contractile properties is to alter contractile proteins such as myosin heavy chain (MyHC), which is known to demonstrate isoform plasticity in response to disease states. The purpose of this study was to examine myocyte functionality over the complete range of MyHC expression in heart, from 100% alpha-MyHC to 100% beta-MyHC, using euthyroid and… CONTINUE READING
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Age dependence of isometric crossbridge cycling and myosin heavy chain isoform expression in human ventricular myocytes (Abstract)

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2 Excerpts

Alpha - MyHC dependent acceleration of the rate of force development in rat myocardium ( Abstract )

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