Power of PTEN/AKT: Molecular switch between tumor suppressors and oncogenes.

@article{Xie2016PowerOP,
  title={Power of PTEN/AKT: Molecular switch between tumor suppressors and oncogenes.},
  author={Yingqiu Xie and Sanzhar Naizabekov and Zhanlin Chen and Tursonjan Tokay},
  journal={Oncology letters},
  year={2016},
  volume={12 1},
  pages={375-378}
}
An increasing amount of evidence has shown that tumor suppressors can become oncogenes, or vice versa, but the mechanism behind this is unclear. Recent findings have suggested that phosphatase and tensin homolog (PTEN) is one of the powerful switches for the conversion between tumor suppressors and oncogenes. PTEN regulates a number of cellular processes, including cell death and proliferation, through the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR… CONTINUE READING
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