Power comparisons between similarity-based multilocus association methods, logistic regression, and score tests for haplotypes.

@article{Lin2009PowerCB,
  title={Power comparisons between similarity-based multilocus association methods, logistic regression, and score tests for haplotypes.},
  author={W. Y. Lin and Daniel J. Schaid},
  journal={Genetic epidemiology},
  year={2009},
  volume={33 3},
  pages={183-97}
}
Recently, a genomic distance-based regression for multilocus associations was proposed (Wessel and Schork [2006] Am. J. Hum. Genet. 79:792-806) in which either locus or haplotype scoring can be used to measure genetic distance. Although it allows various measures of genomic similarity and simultaneous analyses of multiple phenotypes, its power relative to other methods for case-control analyses is not well known. We compare the power of traditional methods with this new distance-based approach… CONTINUE READING

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