Powder properties and their influence on dry powder inhaler delivery of an antitubercular drug

  title={Powder properties and their influence on dry powder inhaler delivery of an antitubercular drug},
  author={Vasu V. Sethuraman and Anthony JR Hickey},
  journal={AAPS PharmSciTech},
The purpose of this study was to determine if aerosol delivery of drug loaded microparticles to lungs infected withMycobacterium tuberculosis may be achieved by predicting dispersion of dry powders through knowledge of particle surface properties. Particle sizes of rifampicin-loaded poly(lactide-co-glycolide) microparticles (R-PLGA), rifampicin alone, and lactose and maltodextrin carrier particles (bulk and 75-125-μm sieved fractions) were determined by electron microscopy for the projected… CONTINUE READING
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Dispersion and Characterization of Pharmaceutical Dry Powder Aerosols

  • CA Dunbar, AJ Hickey, P. Holzner
  • KONA,
  • 1998
2 Excerpts

The use of solubility parameters in pharmaceutical dosage form design

  • BC Hancock, P York, RC. Rowe
  • Int J Pharm
  • 1997
1 Excerpt

A comparison of two contact angle measurement methods and inverse gas chromatography to assess the surface energies of theophylline and caffeine

  • JW Dove, G Buckton, C. Doherty
  • Int J Pharm
  • 1996
1 Excerpt

Determination of the surface properties of two batches of salbutamol sulphate by inverse gas chromatography

  • MD Ticehurst, RC Rowe, P. York
  • Int J Pharm
  • 1994
3 Excerpts

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