Powder on hepatic steatosis in the rats fed with high fat diet

  • Ramin Kaffashi Elahi
  • Published 2012


The aim of the present study was to evaluate the preventive effects of Turmeric (Curcuma Longa Linn.) powder on rat high fat diet-induced hepatic steatosis. For this purpose, male Wistar rats were treated in 4 experimental groups including: 1-healthy control group given standard diet, 2high fat diet group for induction of hepatic steatosis, 3high fat diet plus Clofibrate (320 mg/kg) as positive control, and 4high fat diet plus Turmeric powder (5%) for protection of liver steatosis, at a period of 6 weeks. At the end of experiment, the groups were compared considering serum lipid profile, serum biomarkers of liver tissue injury and liver histopathological changes. The lipid peroxidation product and the activities of antioxidant enzymes were measured as indicators of antioxidation in liver tissue. After 6 weeks, high fat diet caused deleterious metabolic effects, including hypertriglyceridemia, hypercholesterolemia and liver dysfunction. Rats fed high fat diet alone showed increased activities of hepatocellular enzymes in plasma, significant decline in antioxidants, and elevated lipid peroxidation indices in liver. Turmeric treatment significantly reduced elevated markers of liver tissue injury and lipid peroxidation product (MDA), and brought back the liver antioxidants and the over accumulation lipids in serum towards normal. Histopathology of the liver confirmed the changes induced by high fat diet and the hepatoprotective effect of Turmeric powder. The results obtained showed turmeric powder exerts protective effects against hepatic steatosis in rats fed with high fat diet possibly through its antioxidant actions. [Ramin Kaffashi Elahi. Preventive effects of Turmeric (Curcuma longa Linn.) Powder on hepatic steatosis in the rats fed with high fat diet. Life Sci J 2012;9(4):5462-5468] (ISSN:1097-8135). http://www.lifesciencesite.com. 809

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@inproceedings{Elahi2012PowderOH, title={Powder on hepatic steatosis in the rats fed with high fat diet}, author={Ramin Kaffashi Elahi}, year={2012} }