Povidone‐iodine wound irrigation: A word of caution

  title={Povidone‐iodine wound irrigation: A word of caution},
  author={Randolph H L Wong and Emily C. W. Hung and Vivien Wong and Innes Y. P. Wan and Calvin S H Ng and Song Wan and Malcolm John Underwood},
  journal={Surgical Practice},
Iodine‐based disinfectants are widely used by various surgical specialties to prevent and treat wound infection; however, its detrimental effects are often overlooked. We hereby report a dialysis‐dependent renal failure patient with clinical manifestation of systemic iodine toxicity after irrigation of an infected mediastinal wound with povidone‐iodine solution. Further study is required to determine the systemic absorption and side‐effect profile of povidone‐iodine especially when used for… 

Topical application of povidone‐iodine before wound closure is associated with significant increase in serum iodine level

To determine serum iodine level before and after local application of povidone‐iodine before wound closure in cardiac surgery patients, little is known concerning the absorption profile and potential systemic toxicity.

Iodine pleurodesis--a word of caution.

  • R. WongC. NgM. Underwood
  • Medicine, Biology
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • 2012
It is suggested that a single application of povidone–iodine to subcutaneous tissue can cause a significant increase in post-operative serum iodine levels and possible altered mental status in susceptible individuals, and proposed that patients with malignant pleural effusion might have impaired pleural absorption and hence lower the chance of systemic iodine toxicity.

Safety Profile of the Use of Iodopovidone for Pleurodesis in Patients with Malignant Pleural Effusion

Adverse events after iodopovidone pleurodesis in patients with MPE are common and similar in the two doses studied, and no difference was observed between groups with regard to adverse events, CRP levels, efficacy, or quality of life.



Povidone‐Iodine–Induced Burn: Case Report and Review of the Literature

Clinicians need to be aware of this possible povidone‐iodine–associated adverse drug reaction, and of preventive measures, given the widespread use of povids and the potential for development of infection after a burn.

Dilute Povidone‐Iodine Solutions Inhibit Human Skin Fibroblast Growth

  • A. BalinL. Pratt
  • Medicine
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • 2002
The results indicate that caution should be used when povidone-iodine is placed on an open wound, and that prolonged contact with viable uncontaminated tissue should be avoided.

Accelerated treatment of postpneumonectomy empyema: a binational long-term study.

Effect of povidone-iodine on anastomotic tumor growth in an experimental model of colorectal cancer surgery.

Implantation of viable exfoliated tumor cells may be responsible for the local recurrence of colorectal cancer and povidone-iodine (PVP-I) had effective cytotoxicity.


  • RHL Wong et al. 124 Surgical Practice
  • 2009