Pourquoi la kétamine ?

@article{Dual2021PourquoiLK,
  title={Pourquoi la k{\'e}tamine ?},
  author={C. Dual{\'e} and F. Aubrun},
  journal={Douleur Et Analgesie},
  year={2021}
}

References

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Increased Experimental Pain Sensitivity in Chronic Pain Patients Who Developed Opioid Use Disorder
TLDR
Findings suggest that experimental pain testing may be a novel technique in identifying patients with chronic pain likely to develop OUD, in that they are likely to evidence exacerbated temporal summation and to rate the associated pain as more severe. Expand
Ketamine and Magnesium for Refractory Neuropathic Pain.
TLDR
The hypothesis that ketamine provided pain relief at 5 weeks and cognitive-emotional benefit versus placebo and that a combination with magnesium had any additional analgesic effect was refuted. Expand
Ketamine and Magnesium for Refractory Neuropathic Pain: A Randomized, Double-blind, Crossover Trial.
TLDR
The hypothesis that ketamine provided pain relief at 5 weeks and cognitive-emotional benefit versus placebo and that a combination with magnesium had any additional analgesic effect was refuted. Expand
Ketamine Infusions for Chronic Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
TLDR
Evidence suggests that IV ketamine provides significant short-term analgesic benefit in patients with refractory chronic pain, with some evidence of a dose-response relationship. Expand
Plasticity in the dynamic pain connectome associated with ketamine-induced neuropathic pain relief.
TLDR
Findings indicate that pain relief from ketamine arises from a combination of flexible pretreatment FC of the descending antinocieptive pathway together with plasticity (reduction) of cross-network connectivity of the default mode network with sensorimotor and salience networks. Expand
Brain Dynamics and Temporal Summation of Pain Predicts Neuropathic Pain Relief from Ketamine Infusion
TLDR
It is suggested that brain and behavioral measures have the potential to prognosticate and develop ketamine-based personalized pain therapy and point to mechanisms by which ketamine can relieve pain. Expand
Ketamine for chronic non‐cancer pain: A meta‐analysis and trial sequential analysis of randomized controlled trials
TLDR
A meta‐analysis was performed to assess the efficacy of ketamine during chronic non‐cancer pain conditions and found inconsistency across studies investigating the effect of this compound for chronic pain management. Expand
Absence of long‐term analgesic effect from a short‐term S‐ketamine infusion on fibromyalgia pain: A randomized, prospective, double blind, active placebo‐controlled trial
TLDR
It is argued that a short‐term infusion of ketamine is insufficient to induce long‐term analgesic effects in fibromyalgia patients and limited and restricted in duration to its pharmacokinetics. Expand
Population pharmacokinetic—pharmacodynamic modeling of ketamine‐induced pain relief of chronic pain
TLDR
A pharmacokinetic—pharmacodynamic (PK—PD) modeling study on the effect of S(+)‐ketamine on pain scores in Complex Regional Pain Syndrome type 1 (CRPS‐1) patients is performed. Expand
Ketamine produces effective and long-term pain relief in patients with Complex Regional Pain Syndrome Type 1
TLDR
In a population of mostly chronic CRPS‐1 patients with severe pain at baseline, a multiple day ketamine infusion resulted in significant pain relief without functional improvement. Expand
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