Pouchitis in a rat model of ileal J pouch-anal anastomosis.

  title={Pouchitis in a rat model of ileal J pouch-anal anastomosis.},
  author={Khaled O. Shebani and Arthur F. Stucchi and Brent Fruin and James P. McClung and Denise Gee and Eve R. Beer and Wayne W. Lamorte and James M. Becker},
  journal={Inflammatory bowel diseases},
  volume={8 1},
Endorectal ileal pouch-anal anastomosis (IPAA) has become the operation of choice for patients with chronic ulcerative colitis. Although this procedure improves the quality of life, pouchitis remains a significant postoperative complication. Because our understanding of the pathophysiology of pouchitis may, in part, be due to the lack of small animal model, our aim was to develop a model of IPAA in a rat that mimics its clinical counterpart. Colectomy, proctectomy, construction of an ileal J… CONTINUE READING
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