Pou5f1 contributes to dorsoventral patterning by positive regulation of vox and modulation of fgf8a expression.

@article{Belting2011Pou5f1CT,
  title={Pou5f1 contributes to dorsoventral patterning by positive regulation of vox and modulation of fgf8a expression.},
  author={Heinz-Georg Belting and Bj{\"o}rn Wendik and Karen Lunde and Manuel Leichsenring and Rebecca M{\"o}ssner and Wolfgang Driever and Daria Onichtchouk},
  journal={Developmental biology},
  year={2011},
  volume={356 2},
  pages={323-36}
}
Pou5f1/Oct-4 in mice is required for maintenance of embryonic pluripotent cell populations. Zebrafish pou5f1 maternal-zygotic mutant embryos (spiel ohne grenzen; MZspg) lack endoderm and have gastrulation and dorsoventral patterning defects. A contribution of Pou5f1 to the control of bmp2b, bmp4 and vox expression has been suggested, however the mechanisms remained unclear and are investigated in detail here. Low-level overexpression of a Pou5f1-VP16 activator fusion protein can rescue… CONTINUE READING