Pou5f1/oct4 in pluripotency control: insights from zebrafish.

@article{Onichtchouk2012Pou5f1oct4IP,
  title={Pou5f1/oct4 in pluripotency control: insights from zebrafish.},
  author={Daria Onichtchouk},
  journal={Genesis},
  year={2012},
  volume={50 2},
  pages={75-85}
}
Gastrulation in vertebrates is a conserved process, which involves transition from cellular pluripotency to early precursors of ectoderm, mesoderm, and endoderm. Pluripotency control during this stage is far from being understood. Recent genetic and transcriptomic studies in zebrafish suggest that the core pluripotency transcription factors (TFs) Pou5f1 and TFs of the SoxB1 group are critically involved in large-scale temporal coordination of gene expression during gastrulation. A significant… CONTINUE READING