Pou homeodomain protein OCT1 is implicated in the expression of the caudal-related homeobox gene Cdx-2.

@article{Jin2001PouHP,
  title={Pou homeodomain protein OCT1 is implicated in the expression of the caudal-related homeobox gene Cdx-2.},
  author={Tianru Jin and Huiping Li},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 18},
  pages={14752-8}
}
The caudal homeobox gene Cdx-2 is a transcriptional activator for approximately a dozen genes specifically expressed in pancreatic islets and intestinal cells. It is also involved in preventing the development of colorectal tumors. Studies using "knockout" approaches demonstrated that Cdx-2 is haplo-insufficient in certain tissues including the intestines but not the pancreatic islets. The mechanisms, especially transcription factors, which regulate Cdx-2 expression, are virtually unknown. We… CONTINUE READING

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