Potentiative interactions between caffeine and various teratogenic agents.

  title={Potentiative interactions between caffeine and various teratogenic agents.},
  author={E. J. Ritter and William J. Scott and J. Gerald Wilson and P R Mathinos and J. L. Randall},
  volume={25 1},
Acetazolamide and inhibitors of DNA synthesis (hydroxyurea, 5-fluoro-2'-deoxyuridine), RNA synthesis (actinomycin D), and protein synthesis (cycloheximide, emetine) were each administered to pregnant rats together with caffeine at doses where each agent alone caused minimal embryotoxicity. Caffeine co-administered with any of the other agents induced a powerful potentiative response. It is not clear from the present experiments whether much lower caffeine dosage, as normally encountered in… 
Potentiating effects of caffeine on teratogenicity of alkylating agents in mice.
The teratogenicity of mitomycin C was significantly potentiated by caffeine at a dose as low as 12.5 mg/kg, but similar potentiation was not observed for x-ray, MNNG, thio-TEPA, and cyclophosphamide.
Coadministration of methylxanthines and inhibitor compounds potentiates teratogenicity in Xenopus embryos.
The teratogenicity of the protein synthesis inhibitors was greatly increased upon coadministration with each methylxanthine, even though they are typically not very teratogenic by themselves, and co Administration of the DNA synthesis inhibitors with theobromine did not result in ter atogenic potentiation.
Potentiation of teratogenesis.
  • E. Ritter
  • Biology
    Fundamental and applied toxicology : official journal of the Society of Toxicology
  • 1984
Teratology studies were conducted with rats using combinations of a variety of agents including inhibitors of DNA, RNA, protein, and purine synthesis, and most combinations showed potentiation of embryolethality and teratogenesis as compared to that seen with the use of the individual agents.
Potentiating Effects of Caffeine on Ephedrine-Induced Conotruncal Malformations of the Embryonic Heart in the Chick
The potentiating effects of caffeine on the teratogenic activity of ephedrine in the embryonic chick cardiovascular system is observed.
Combined prenatal toxicity of 6-mercaptopurine riboside and hydroxyurea in mice.
The interaction between these two compounds with regard to teratogenicity in NMRI mice was investigated and the influence of HU on the 6-MPr-induced DNA modification was determined by measuring the incorporation of 6-thioguanine into the DNA of day-11 embryos.
Potentiating effect of caffeine on embryotoxicity of cyclophosphamide treatment in vivo during the preimplantation period.
The data are providing evidence that CF at subthreshold doses can potentiate the embryotoxicity of an alkylating agent in vivo even before implantation, and suggest that CF can inhibit the repair of CPA-induced DNA damage in preimplantation embryos.
Inhibitory effect of caffeine on 5-azacytidine-induced digital malformations in the rat.
The malformation results support the view that caffeine inhibits the processes leading to malformation expression, but the relation between its suppressive effect on malformations and its enhancing effect on fetal mortality is unclear.
Studies on the relation between alkylating agents-induced chromosomal aberrations and their embryotoxicities in mice
The simultaneous administration of caffeine reduced the embryolethality of MMS while the frequency of chromosomal aberrations increased significantly, suggesting that the reduction of the embryos of mouse embryos may be ascribe to the toxic effects of M MS which must be antagonized by caffeine.
Potentiation of acetazolamide induced ectrodactyly in SWV and C57BL/6J mice by cadmium sulfate.
In the present study administration of CdSO4 and acetazolamide in combination to either strain of mice potentiates the incidence of forelimb ectrodactyly, suggesting a common mechanism of teratogenesis.


It is established that chemical teratogenic agents can be used in certain combinations at low, even subthreshold dosages, to produce malformations at a rate considerably above the rate expected when only one agent is used alone.
A current assessment of the mutagenic and teratogenic effects of caffeine.
An attempt is made to draw pertinent data from the experimental studies of mutagenesis and teratogenesis, in conjunction with studies of caffeine metabolism and distribution in mammalian organisms including man, and to interrelate these factors in terms of mechanism of action and pharmacokinetics.
Reduction in frequency of fetopathic effects of caffeine in mice by pretreatment with propranolol.
The fetoputhic effects of caffeine were significantly reduced by pretreatment with propranolol at all dosages; and it was hypothesized that the β-adrenergic actions of catecholamines caused to be released by caffeine induce fetal circulatory disturbance, which leads to fetal abnormalities.
Effects of methylated xanthines on mammalian cells treated with bifunctional alkylating agents
An influence by MXs on initiation of DNA synthesis in damaged replicons is demonstrated, and it is proposed that this effect is primarily responsible for the synergistic lethal properties of these drugs.
Teratogenic action of carbonic anhydrase inhibitors in the rat.
Analysis of embryos from untreated females revealed that carbonic anhydrase does not appear in measurable amounts in the developing rat until the thirteenth day of gestation, making highly unlikely the possibility that the drug's teratogenic action is associated with carbonicAnhydrase inhibition in the embryo.
Teratogenic Action of a Hypocaloric Diet and Small Doses of Cortisone.∗
  • H. Kalter
  • Medicine
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1960
Summary Two relatively small doses of cortisone acetate administered to pregnant mice caused 1.4 and 12.0% cleft palate, respectively, in the offspring. A hypocaloric diet, consisting of about 40% of
The action of caffeine on X-irradiated HeLa cells. II. Synergistic lethality.
Dose-response curves were also obtained for synchronous cells at various phases of the cell cycle, and results were obtained at all cell ages, but the magnitude of the effect is age dependent.