Potentiation of tumor necrosis factor-alpha-induced tumor cell apoptosis by a small molecule inhibitor for anti-apoptotic protein hPEBP4.

@article{Qiu2010PotentiationOT,
  title={Potentiation of tumor necrosis factor-alpha-induced tumor cell apoptosis by a small molecule inhibitor for anti-apoptotic protein hPEBP4.},
  author={Jianming Qiu and Jianfeng Xiao and Chaofeng Han and Nan Li and Xu Shen and Hualiang Jiang and Xuetao Cao},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 16},
  pages={12241-7}
}
hPEBP4 (human phosphatidylethanolamine-binding protein 4) has been identified to be able to potentiate the resistance of breast, prostate, and ovarian cancers, with the preferential expression of hPEBP4, to tumor necrosis factor-alpha (TNF-alpha) or tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis, suggesting that inhibitors targeting the anti-apoptotic protein hPEBP4 may be useful to increase the sensitivity of hPEBP4-expressing cancer cells to TNF-alpha or… CONTINUE READING

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Anti-tumor Effect of Small Molecule Inhibitor

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