Potentiation of transforming growth factor (TGF-β1) by natural coral and fibrin in a rabbit cranioplasty model

@article{Arnaud1994PotentiationOT,
  title={Potentiation of transforming growth factor (TGF-β1) by natural coral and fibrin in a rabbit cranioplasty model},
  author={Eric Arnaud and Caroline Morieux and Marc Wybier and M. Christine de Vernejoul},
  journal={Calcified Tissue International},
  year={1994},
  volume={54},
  pages={493-498}
}
The association of a biodegradable material and a growth factor could be of clinical value for treating bone defects. We therefore tested the association of transforming growth factor β (TGF-β1) in fibrin glue and coral granules to heal skull defects in rabbits. Adult rabbits underwent a double trepanation symmetrically in both parietal bones. Using histomorphometry, we compared bone repair after 1 month in control animals (n=5) and in animals treated with either TGF-β1 as a single injection of… CONTINUE READING