Potentiation of thioacetamide liver injury in diabetic rats is due to induced CYP2E1.

@article{Wang2000PotentiationOT,
  title={Potentiation of thioacetamide liver injury in diabetic rats is due to induced CYP2E1.},
  author={Tao Wang and Kartik Shankar and Martin J. J. Ronis and Harihara M. Mehendale},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2000},
  volume={294 2},
  pages={
          473-9
        }
}
Thioacetamide (TA)-induced hepatotoxicity is potentiated in streptozotocin (STZ)-induced diabetic rats. The relative roles of CYP2E1 and FMO1 in the mechanism of TA-associated liver injury were investigated. In the STZ-induced diabetic rat, hepatic CYP2E1 protein concentration and p-nitrophenol hydroxylation were induced 8- and 5.6-fold, respectively. Pretreatment with the CYP2E1 inducer, isoniazid (INH, 250 mg/kg, i.p.) before TA (300 mg/kg, i.p.) administration significantly increased TA… CONTINUE READING
Highly Cited
This paper has 47 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Saturation toxicokinetics of thioacetamide: role in initiation of liver injury.

Drug metabolism and disposition: the biological fate of chemicals • 2005
View 5 Excerpts
Highly Influenced

Type 1 diabetic mice are protected from acetaminophen hepatotoxicity.

Toxicological sciences : an official journal of the Society of Toxicology • 2003
View 7 Excerpts
Highly Influenced

Cytochrome P4502E1 induction increases thioacetamide liver injury in diet-restricted rats.

Drug metabolism and disposition: the biological fate of chemicals • 2001
View 8 Excerpts
Method Support
Highly Influenced

Protective effect of type 2 diabetes on acetaminophen-induced hepatotoxicity in male Swiss-Webster mice.

The Journal of pharmacology and experimental therapeutics • 2006
View 6 Excerpts
Highly Influenced