Potentiation of the reversal activity of SDZ PSC833 on multi-drug resistance by an anti-P-glycoprotein monoclonal antibody MRK-16.

Abstract

SDZ PSC833 (PSC833), an analogue of cyclosporines, is one of the most potent modulators of multi-drug resistance (MDR). We previously reported that MRK-16, an anti-P-glycoprotein MAb, enhanced MDR reversal activity of cyclosporin A (CsA) through inhibition of P-glycoprotein-mediated CsA transport. We have examined here whether MRK-16 can enhance MDR… (More)

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@article{Naito1996PotentiationOT, title={Potentiation of the reversal activity of SDZ PSC833 on multi-drug resistance by an anti-P-glycoprotein monoclonal antibody MRK-16.}, author={Mariko Fujimoto Naito and T Watanabe and Haruhito Tsuge and Teruhide Koyama and Tomoko Oh-hara and Takashi Tsuruo}, journal={International journal of cancer}, year={1996}, volume={67 3}, pages={435-40} }