Potentiation of the function of Hageman factor fragments by high molecular weight kininogen.

@article{Liu1977PotentiationOT,
  title={Potentiation of the function of Hageman factor fragments by high molecular weight kininogen.},
  author={C. Y. Liu and Cheryl F. Scott and Andranik Bagdasarian and Jack V. Pierce and Allen P. Kaplan and Robert W. Colman},
  journal={The Journal of clinical investigation},
  year={1977},
  volume={60 1},
  pages={
          7-17
        }
}
Patients lacking high molecular weight (HMW) kininogen have profound abnormalities of the Hageman factor-dependent pathways of coagulation, kinin formation, and fibrinolysis. The ability of HMW kininogen to potentiate the Hageman factor fragments (HFf) activation of prekallikrein and Factor XI in plasma was studied. HFf only partially converted Factor XI to XIa and prekallikrein to kallikrein in plasma deficient in HMW kininogen (Williams trait), while enhanced activation of Factor XI and… Expand
Abnormalities in the contact activation through factor XII in Fujiwara trait: a deficiency in both high and low molecular weight kininogens with low level of prekallikrein.
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References

SHOWING 1-10 OF 20 REFERENCES
Williams trait. Human kininogen deficiency with diminished levels of plasminogen proactivator and prekallikrein associated with abnormalities of the Hageman factor-dependent pathways.
TLDR
Kininogen is a critical factor required for the functioning of Hageman factor-dependent coagulation and fibrinolysis and for the activation of prekallikrein. Expand
Evidence that Fitzgerald factor counteracts inhibition by kaolin or ellagic acid of the amidolytic properties of a plasma kallikrein.
TLDR
Fitzgerald factor enhanced amidolysis of both normal and Fitzgerald-trait plasmas exposed to kaolin, effects not duplicated by cytochrome C or IgG, suggesting that these agents may inhibit the negative charges of kaolin or ellagic acid. Expand
THE FIRST COMPONENT OF THE KININ-FORMING SYSTEM IN HUMAN AND RABBIT PLASMA
TLDR
The isolation and characterization of the first component of the kinin-forming system in human and rabbit plasma are presented and evidence is presented that it is identical with Hageman factor (clotting factor XII), which promoted clotting of factor XII-deficient plasma. Expand
A Pre-Albumin Activator of Prekallikrein
TLDR
Prolonged dialysis of a partially purified preparation of active Hageman factor resulted in the development of pre-albumin bands in the position previously noted for the highly purified prekallikrein activator. Expand
Flaujeac trait. Deficiency of human plasma kininogen.
TLDR
This is the first demonstration of biological function for a kininogen apart from its role as a substrate for kallikreins, and the plasma pathways of intrinsic coagulation, fibrinolysis, kinin formation, and PF/dil generation are dependent upon HMW-kininogen. Expand
Kininogen deficiency in Fitzgerald trait: role of high molecular weight kininogen in clotting and fibrinolysis.
TLDR
Plasma from an asymptomatic person with defects in blood coagulation, release of kinin, and evolution of fibrinolytic activity upon contact with a foreign surface was deficient in Kininogen, and Fitzgerald factor appears to be a high molecular weight kininogen. Expand
Defective Activation of Clotting, Fibrinolytic, and Permeability‐Enhancing Systems in Human Fletcher Trait Plasma
TLDR
Fletcher trait plasma appeared to be deficient in a plasma prekallikrein, which most probably participates in the functioning of activated HF, which emphasize the intimate relationships among clotting, fibrinolysis, and enhancement of vascular permeability. Expand
Evidence for a new plasma thromboplastin factor. I. Case report, coagulation studies and physicochemical properties.
TLDR
Physical and chemical properties of plasma correcting the defect in vitro indicated that the defect is closely related to that found in PTA and HF deficient plasma. Expand
The partial thromboplastin time with kaolin. A simple screening test for first stage plasma clotting factor deficiencies.
TLDR
Waaler has demonstrated that long times with normal plasma may be caused by inadequate contact activation of the test plasma when, and it is shown that the partial thromboplastin time technic is not widely used in clinical laboratories. Expand
Factor V: An Activator of Factor Xa in the Absence of Prothrombin
  • R. Colman
  • Chemistry, Medicine
  • British journal of haematology
  • 1970
TLDR
Factor V potentiates the arginine esterase activity of factor Xa more than three‐fold in the presence of phospholipid and calcium but in the absence of prothrombin. Expand
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