Potentiation of the calcium-channel currents of internally perfused mammalian heart cells by repetitive depolarization.

@article{Lee1987PotentiationOT,
  title={Potentiation of the calcium-channel currents of internally perfused mammalian heart cells by repetitive depolarization.},
  author={Kevin Sang Lee},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 11},
  pages={
          3941-5
        }
}
  • Kevin Sang Lee
  • Published 1987 in
    Proceedings of the National Academy of Sciences…
The Ca2+ current of single ventricular cells perfused internally by the suction-pipette method can be increased ("potentiated") progressively with repeated stimulation. In Na+- and K+-free external solution containing Ca+, the potentiation response begins to appear at a step potential to -20 mV from a holding potential of -90 mV, reaching a maximum at 0-10 mV. Thus, maximal potentiation coincides with peak inward Ca2+ current. The time course of potentiation development and decline is very slow… CONTINUE READING
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