Corpus ID: 5801175

Potentiation of the antitumor activity of methotrexate by concurrent infusion of thymidine.

@article{Semon1978PotentiationOT,
  title={Potentiation of the antitumor activity of methotrexate by concurrent infusion of thymidine.},
  author={J. Semon and G. Grindey},
  journal={Cancer research},
  year={1978},
  volume={38 9},
  pages={
          2905-11
        }
}
  • J. Semon, G. Grindey
  • Published 1978
  • Medicine
  • Cancer research
  • Abstract The effects of normal metabolites on the toxicity and antitumor activity of methotrexate against leukemia L1210 in DBA/2J mice were evaluated by a system that allows for long-term continuous i.v. infusion of unrestrained mice. In normal female DBA/2J mice, the infusion of methotrexate alone for 48 hr produced a 50% lethal dose of 6 mg/kg/day. Coadministration of thymidine (5 g/kg/day) and methotrexate, followed by an additional 48 hr of thymidine alone, dramatically reduced toxicity… CONTINUE READING
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