Potentiation of the Kv1 family K(+) channel by cortisone analogues.

Abstract

The Kv1 family voltage-dependent K(+) channels are essential for termination of action potentials in neurons and myocytes. These channels form a stable complex with their beta subunits (Kvβ), some of which inhibit channel activity. Cortisone potentiates Kv1 channel by binding to Kvβ and promoting its dissociation from the channel, but its half-maximum… (More)
DOI: 10.1021/cb300233y

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