Potentiation of the Effect of Lonidamine by Quercetin in MCF-7 human breast cancer cells through downregulation of MMP-2/9 mRNA Expression.

@article{Ozkan2020PotentiationOT,
  title={Potentiation of the Effect of Lonidamine by Quercetin in MCF-7 human breast cancer cells through downregulation of MMP-2/9 mRNA Expression.},
  author={Erva Ozkan and Filiz Bakar-Ates},
  journal={Anais da Academia Brasileira de Ciencias},
  year={2020},
  volume={92 4},
  pages={
          e20200548
        }
}
Combination therapies are becoming increasingly important to develop an effective treatment in cancer. Lonidamine is frequently used in cancer treatment, but it's often preferred to be used in combination with other drugs because of its side effects. In the present study, the efficacy of the combination of lonidamine with quercetin, a flavonoid of natural origin, on human MCF-7 breast cancer cells was evaluated. The results showed that the combined use of the compounds significantly increased… 

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References

SHOWING 1-10 OF 45 REFERENCES
Improved synergistic anticancer efficacy of quercetin in combination with PI-103, rottlerin, and G0 6983 against MCF-7 and RAW 264.7 cells
TLDR
Overall results of the current study suggested that QUE improves the synergistic anticancer efficacy in combination with PI-103, ROT, and G0 6983 in MCF-7 and RAW 264.7 cells.
Quercetin enhances adriamycin cytotoxicity through induction of apoptosis and regulation of mitogen-activated protein kinase/extracellular signal-regulated kinase/c-Jun N-terminal kinase signaling in multidrug-resistant leukemia K562 cells.
Multidrug resistance (MDR) has become a significant challenge in chemotherapeutic treatment of cancer. Quercetin, a naturally occurring flavonoid, has been found to possess anti-proliferative,
Differential Effects of Quercetin and Two of Its Derivatives, Isorhamnetin and Isorhamnetin-3-glucuronide, in Inhibiting the Proliferation of Human Breast-Cancer MCF-7 Cells.
TLDR
The results showed that Que, IS, and I3G could dose-dependently inhibit the growth of MCF-7 cells, and the cytotoxic effect was ranked as Que > IS > I2G, and Que possess strong cytot toxic effects through an ROS-dependent apoptosis pathway in MCF -7 cells.
Quercetin Potentiates Doxorubicin Mediated Antitumor Effects against Liver Cancer through p53/Bcl-xl
TLDR
Results indicate that quercetin potentiated the antitumor effects of DOX on liver cancer cells while protecting normal liver cells, and may be beneficial in a combined treatment with DOX for increased therapeutic efficacy against liver cancer.
Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-κB and matrix metalloproteinase-2/-9 signaling pathways.
TLDR
It is concluded that inhibition of migration and invasion of SAS cells by quercetin is associated with the down-regulation of PKC and RhoA by blocking MAPK and PI3K/AKT signaling pathways and NF-κB and uPA, resulting in inhibition of MMP-2 and M MP-9 signaling.
Effects of Quercetin-Loaded Nanoparticles on MCF-7 Human Breast Cancer Cells
TLDR
SLN significantly enhanced the toxic effect of QT against human breast cancer cells and induced a significant decrease in the viability and proliferation of MCF-7 cells, compared to the free QT.
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