Potentiation of temozolomide-induced cytotoxicity: a comparative study of the biological effects of poly(ADP-ribose) polymerase inhibitors.

@article{Boulton1995PotentiationOT,
  title={Potentiation of temozolomide-induced cytotoxicity: a comparative study of the biological effects of poly(ADP-ribose) polymerase inhibitors.},
  author={S. Boulton and Lucy C. Pemberton and Julia K. Porteous and Nicola J Curtin and Roger J. Griffin and Bernard T Golding and Barbara W. Durkacz},
  journal={British Journal of Cancer},
  year={1995},
  volume={72},
  pages={849 - 856}
}
Four poly(ADP-ribose) polymerase (PADPRP) inhibitors [3-aminobenzamide, benzamide, 3,4-dihydro-5-methoxyisoquinolin-1(2H)-one (PD 128763) and 8-hydroxy-2-methylquinazolin-4(3H)-one (NU1025)] were compared with respect to their effects on a number of biological end points. The following parameters were assessed: their ability to inhibit the enzyme in permeabilised L1210 cells; their ability to potentiate the cytotoxicity of temozolomide (including the cytotoxicity of the compounds per se); their… CONTINUE READING

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