Potentiation of systemic morphine analgesia in humans by proglumide, a cholecystokinin antagonist.

@article{Price1985PotentiationOS,
  title={Potentiation of systemic morphine analgesia in humans by proglumide, a cholecystokinin antagonist.},
  author={Donald D. Price and A von der Gruen and Julius Miller and Amir Rafii and Colin B Price},
  journal={Anesthesia and analgesia},
  year={1985},
  volume={64 8},
  pages={
          801-6
        }
}
Proglumide, a cholecystokinin antagonist, potentiates analgesia produced in rats by morphine and endogenous opiates, and appears to reverse tolerance in rats to opiate analgesia. Therefore, proglumide and other cholecystokinin antagonists may be clinically valuable. We have tested proglumide's possible opiate analgesic potentiating effects by examining, in volunteers, the effects of morphine and proglumide on human pain visual analogue scale responses to 45-51 degrees C skin temperature stimuli… CONTINUE READING
BETA

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

Similar Papers

Loading similar papers…