Potentiation of simian immunodeficiency virus (SIV)-specific CD4(+) and CD8(+) T cell responses by a DNA-SIV and NYVAC-SIV prime/boost regimen.

@article{Hel2001PotentiationOS,
  title={Potentiation of simian immunodeficiency virus (SIV)-specific CD4(+) and CD8(+) T cell responses by a DNA-SIV and NYVAC-SIV prime/boost regimen.},
  author={Zdenek ZH Hel and Wen Po Tsai and Angela Thornton and J{\'a}nos Nacsa and Laura Giuliani and Elżbieta Tryniszewska and Monita Poudyal and David J Venzon and Xingyu Wang and John D Altman and David I. Watkins and Wuyuan Lu and Agneta von Gegerfelt and Barbara K Felber and James Tartaglia and George N Pavlakis and Genoveffa Franchini},
  journal={Journal of immunology},
  year={2001},
  volume={167 12},
  pages={7180-91}
}
T cell-mediated immune responses play an important role in the containment of HIV-1 replication. Therefore, an effective vaccine against HIV-1 should be able to elicit high frequencies of virus-specific CD8(+) and CD4(+) T cells. The highly attenuated poxvirus-based vaccine candidate, NYVAC-SIV-gag-pol-env (NYVAC-SIV-gpe), has been shown to induce and/or expand SIV-specific CD4(+) and CD8(+) T cell responses in both naive and infected macaques. In this study, the immunogenicity of NYVAC-SIV-gpe… CONTINUE READING