Potentiation of resveratrol-induced apoptosis by matrine in human hepatoma HepG2 cells.

  title={Potentiation of resveratrol-induced apoptosis by matrine in human hepatoma HepG2 cells.},
  author={Xiuyuan Ou and Yan Chen and Xinxin Cheng and Xumeng Zhang and Qiyang He},
  journal={Oncology reports},
  volume={32 6},
Resveratrol, a natural polyphenolic phytochemical, has received considerable attention due to its potential chemopreventive and chemotherapeutic properties. In the present study, we first evaluated the growth-inhibitory effect of resveratrol on HepG2 cells and explored the underlying molecular mechanisms. Resveratrol inhibited proliferation and induced apoptosis in HepG2 cells via activation of caspase-9 and caspase-3, upregulation of the Bax/Bcl-2 ratio and induction of p53 expression. Cell… CONTINUE READING
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