Potentiation of ovarian OCa-1 tumor radioresponse by poly (L-glutamic acid)-paclitaxel conjugate.

@article{Li2000PotentiationOO,
  title={Potentiation of ovarian OCa-1 tumor radioresponse by poly (L-glutamic acid)-paclitaxel conjugate.},
  author={Chun Li and Shi Ke and Qing Ping Wu and Wayne Tansey and Nancy R. Hunter and Lara Buchmiller and Luka Milas and Chusilp Charnsangavej and Sidney Wallace},
  journal={International journal of radiation oncology, biology, physics},
  year={2000},
  volume={48 4},
  pages={1119-26}
}
PURPOSE It has been shown that paclitaxel (TXL) can strongly enhance tumor cells' sensitivity to radiation. We examined whether the radiosensitizing effect of paclitaxel can be further enhanced when it is delivered systemically as a polymer-drug conjugate that provides enhanced tumor uptake and prolonged release of TXL in the tumor. METHODS AND MATERIALS C3Hf/Kam mice bearing 8-mm murine ovarian OCa-1 tumors were treated with i.v.-injected Poly(L-glutamic acid)-paclitaxel (PG-TXL) at an… CONTINUE READING