Potentiation of olanzapine substitution in rats discriminating clozapine by the D2/3 agonist quinpirole.

@article{Cole2007PotentiationOO,
  title={Potentiation of olanzapine substitution in rats discriminating clozapine by the D2/3 agonist quinpirole.},
  author={Jon C. Cole and Matt Field and Harry R Sumnall and Andrew J. Goudie},
  journal={Behavioural pharmacology},
  year={2007},
  volume={18 3},
  pages={185-90}
}
The D2/3 agonist (+)-4-propyl-9-hydroxynaphthoxazine (PHNO) has been reported to enhance the ability of olanzapine to substitute for clozapine and attenuate olanzapine-induced response suppression in monkeys. These data suggest that the relatively marked D2/3 antagonist actions of olanzapine limit its substitution for clozapine. The work reported here replicated and extended these findings. Twelve rats were trained to discriminate clozapine (5 mg/kg, intraperitoneal) from vehicle in an FR30… CONTINUE READING