Potentiation of methotrexate-induced gastrointestinal toxicity by non-steroidal anti-inflammatory drugs (NSAIDs) and vincristine.
@article{Badr1985PotentiationOM, title={Potentiation of methotrexate-induced gastrointestinal toxicity by non-steroidal anti-inflammatory drugs (NSAIDs) and vincristine.}, author={M. Badr and T. Chen}, journal={Toxicology}, year={1985}, volume={34 4}, pages={ 333-40 } }
Inhibition of intestinal nutrient absorption by the folate antagonist methotrexate (MTX) and the effects of several organic acid drugs and vincristine on MTX-induced gastrointestinal toxicity were investigated. Male Swiss-Webster mice received MTX, 25 mg/kg, i.p. once daily for 4 successive days. Using the everted sac technique, the rates of D-glucose and L-tyrosine transport were decreased by MTX to 10.9 and 6.3 mumol/g/h from control values of 35.0 and 10.0 mumol/g/h, respectively. Probenecid… CONTINUE READING
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