Potentiation of methotrexate-induced gastrointestinal toxicity by non-steroidal anti-inflammatory drugs (NSAIDs) and vincristine.

@article{Badr1985PotentiationOM,
  title={Potentiation of methotrexate-induced gastrointestinal toxicity by non-steroidal anti-inflammatory drugs (NSAIDs) and vincristine.},
  author={Mostafa Z. Badr and Theresa S. Chen},
  journal={Toxicology},
  year={1985},
  volume={34 4},
  pages={
          333-40
        }
}
Inhibition of intestinal nutrient absorption by the folate antagonist methotrexate (MTX) and the effects of several organic acid drugs and vincristine on MTX-induced gastrointestinal toxicity were investigated. Male Swiss-Webster mice received MTX, 25 mg/kg, i.p. once daily for 4 successive days. Using the everted sac technique, the rates of D-glucose and L-tyrosine transport were decreased by MTX to 10.9 and 6.3 mumol/g/h from control values of 35.0 and 10.0 mumol/g/h, respectively. Probenecid… CONTINUE READING