Potentiation of metastasis by cell surface sialomucin complex (rat MUC4), a multifunctional anti-adhesive glycoprotein.

@article{Komatsu2000PotentiationOM,
  title={Potentiation of metastasis by cell surface sialomucin complex (rat MUC4), a multifunctional anti-adhesive glycoprotein.},
  author={Masanobu Komatsu and Lela Ruth Tatum and Norman H. Altman and Coralie A Carothers Carraway and Kermit L. Iii Carraway},
  journal={International journal of cancer},
  year={2000},
  volume={87 4},
  pages={
          480-6
        }
}
Sialomucin complex (SMC), a rat homologue of the human mucin MUC4, is a large membrane-bound mucin complex, originally isolated from highly metastatic ascites 13762 mammary adenocarcinoma cells. When overexpressed, SMC exerts potent anti-adhesive effects, which sterically disrupt molecular interactions for cell-cell and cell-ECM adhesions. SMC similarly suppresses anti-tumor immunity by inhibition of interactions between cytotoxic lymphocytes and target tumor cells. Previously, recombinant… CONTINUE READING
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