Potentiation of kinin analogues by ramiprilat is exclusively related to their degradation.

@article{Dendorfer2001PotentiationOK,
  title={Potentiation of kinin analogues by ramiprilat is exclusively related to their degradation.},
  author={Andreas Dendorfer and S Reibetamann and Sebastian Wolfrum and Walter Raasch and Peter Dominiak},
  journal={Hypertension},
  year={2001},
  volume={38 1},
  pages={142-6}
}
The potentiation of kinin actions represents a cardioprotective property of ACE inhibitors. Although a clear contribution to this effect is related to the inhibition of bradykinin (BK) breakdown, the high efficacy of potentiation and the ability of ACE inhibitors to provoke a B(2)-receptor-mediated response even after receptor desensitization has also triggered hypotheses concerning additional mechanisms of kinin potentiation. The application of kinin analogues with enhanced metabolic stability… CONTINUE READING

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