Potentiation of human α4β2 neuronal nicotinic receptors by a Flustra foliacea metabolite

@article{Sala2005PotentiationOH,
  title={Potentiation of human $\alpha$4$\beta$2 neuronal nicotinic receptors by a Flustra foliacea metabolite},
  author={Francisco Sala and Jos{\'e} Mulet and Krishna P. Reddy and Jos{\'e} Antonio Bernal and Philip Wikman and Luis M. Valor and Lars Peters and Gabriele Maria K{\"o}nig and Manuel Criado and Salvador Sala},
  journal={Neuroscience Letters},
  year={2005},
  volume={373},
  pages={144-149}
}

Desformylflustrabromine Modulates α4β2 Neuronal Nicotinic Acetylcholine Receptor High- and Low-Sensitivity Isoforms at Allosteric Clefts Containing the β2 Subunit

TLDR
Findings from this study will aid in the improved design of dFBr-like PAMs for potential therapeutic use and support the involvement of the principal face of the β2 subunit in dF Br modulation of ACh-induced responses.

Allosteric Modulator Desformylflustrabromine Relieves the Inhibition of α2β2 and α4β2 Nicotinic Acetylcholine Receptors by β-Amyloid1–42 Peptide

TLDR
dFBr is a positive allosteric modulator for both α4β2 and α2β2 subtypes of nAChRs and that it also relieves the blockade of these receptors by Aβ1–42.

Targeting α4β2 nicotinic acetylcholine receptors in central nervous system disorders: perspectives on positive allosteric modulation as a therapeutic approach.

TLDR
The present MiniReview is on the heteromeric α4β2 nAChR, as activity at this subtype contributes to cognitive functioning through interactions with multiple neurotransmitter systems and is implicated in various CNS disorders, for example schizophrenia and Alzheimer's disease.

Allosteric modulation and potential therapeutic applications of heteromeric nicotinic acetylcholine receptors

TLDR
This review will discuss the primary lead compounds identified to date that allosterically potentiate or inhibit heteromeric nAChRs, including α4β2 and α3β4 subtypes, with a focus on the current understanding of these structural and functional relationships.

The Effects of β-Amyloid on α7 Nicotinic Acetylcholine Receptors Expressed in Xenopus Oocytes

TLDR
It is shown that human α7 subunit nAChRs are not activated by β-amyloid42 at 1 pM30 nM concentrations, and that short, seven-second applications of β-Amyloid interact with the α7 nA ChRs to alter the kinetics of the channel, however, the exact mechanism and pattern by which it effects the channel is still unclear.

Positive and negative modulation of nicotinic receptors.

  • H. Arias
  • Biology
    Advances in protein chemistry and structural biology
  • 2010
...

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TLDR
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