Potentiation of histamine-induced itch and flare responses in human skin by the enkephalin analogue FK 33-824, β-endorphin and morphine

@article{Fjellner1982PotentiationOH,
  title={Potentiation of histamine-induced itch and flare responses in human skin by the enkephalin analogue FK 33-824, β-endorphin and morphine},
  author={B. Fjellner and {\"O}sten H{\"a}germark},
  journal={Archives of Dermatological Research},
  year={1982},
  volume={274},
  pages={29-37}
}
The effect of various opioid or putative neurotransmitter peptides on histamine-induced itch and flare responses was studied in humans after intradermal injection. Significant enhancement of the histamine responses was induced by the stable methionine-enkephalin analogue FK 33-824, β-endorphin and morphine. The putative neurotransmitters substance P and vasoactive intestinal polypeptide (VIP) — which moreover are potent histamine liberators — had no enhancing effect. The potentiation induced by… CONTINUE READING
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