Potentiation of halomethane hepatotoxicity: chlordecone and carbon tetrachloride.

  title={Potentiation of halomethane hepatotoxicity: chlordecone and carbon tetrachloride.},
  author={Harihara M. Mehendale},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  volume={4 3 Pt 1},
The propensity for chlordecone to potentiate hepatotoxicity of CCl4 and some related analogs (CHCl3 and CBrCl3) has been well established. The interaction results in potentiation of halomethane hepatotoxicity at incredibly small, nontoxic levels of chlordecone and these halomethanes. Biological effects of such interactions include extensive hepatotoxicity characterized by total hepatic failure as determined by histopathological alterations, hepatic dysfunction, elevation of serum enzymes, and… CONTINUE READING