Potentiation of ethanol-induced hepatic vitamin A depletion by phenobarbital and butylated hydroxytoluene.

@article{Leo1987PotentiationOE,
  title={Potentiation of ethanol-induced hepatic vitamin A depletion by phenobarbital and butylated hydroxytoluene.},
  author={Maria Anna Leo and N Lowe and Charles S. Lieber},
  journal={The Journal of nutrition},
  year={1987},
  volume={117 1},
  pages={
          70-6
        }
}
Administration of ethanol, phenobarbital or butylated hydroxytoluene (BHT) each resulted in significantly lower hepatic vitamin A than in untreated controls. When ethanol was combined with either phenobarbital or BHT, a striking potentiation of the depletion was observed, resulting in hepatic vitamin A values of less than 5% of normal, whether expressed per gram of liver or per 100 g body wt. These effects were observed for both retinol and retinyl esters, measured by high pressure liquid… 
Effects of ethanol and carbon tetrachloride upon vitamin A status of rats.
TLDR
CCl4 (with phenobarbitol), which is a more potent hepatotoxin as evidenced by a more elevated cytochrome P450 and distorted liver morphology, not only reduced liver vitamin A, but also increased serum vitamin A.
Effect of ethanol and vitamin A excess on vitamin A status in the liver, plasma and foetuses of pregnant rats.
  • P. Sundaresan, T. Collins, M. O'donnell
  • Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1994
Hepatic, metabolic and toxic effects of ethanol: 1991 update.
  • C. Lieber
  • Medicine, Biology
    Alcoholism, clinical and experimental research
  • 1991
Until two decades ago, dietary deficiencies were considered to be the only reason for alcoholics to develop liver disease. As the overall nutrition of the population improved, more emphasis was
Flupenthixol and cefotiam: effects on vitamin A metabolism in rats
We examined the alterations in vitamin A metabolism as a result of flupenthixol or cefotiam administration. The impact of these drugs on indices of vitamin A status was evaluated in Brown Norway and
Alcohol, vitamin A, and beta-carotene: adverse interactions, including hepatotoxicity and carcinogenicity.
TLDR
A narrowing of the therapeutic window for retinol and beta-carotene must be taken into account when formulating treatments aimed at correcting vitamin A deficiency, especially in drinking populations.
Mechanisms of ethanol-drug-nutrition interactions.
  • C. Lieber
  • Medicine
    Journal of toxicology. Clinical toxicology
  • 1994
TLDR
A better understanding of the pathology induced by ethanol has now generated improved prospects for therapy, and the contribution of gastric alcohol dehydrogenase to the first pass metabolism of ethanol and alcohol-drug interactions is now recognized.
Developmental effects of combined exposure to ethanol and vitamin A.
  • K. Whitby, T. Collins, P. Sundaresan
  • Chemistry, Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1994
Interaction of Alcohol with Other Drugs and Nutrients
TLDR
The unique ability of P450IIE1 to activate xenobiotic agents now appears to be responsible for the increased susceptibility of the heavy drinker to hepatotoxic industrial solvents, commonly used drugs, over-the-counter medications and chemical carcinogens.
A comparative study on the effects of oral amiodarone and trimeprazine, two in vitro retinyl ester hydrolase inhibitors, on the metabolic availability of vitamin A in rats
TLDR
Amiodarone and trimeprazine have been shown to influence different aspects of retinoid metabolism, namely absorption, storage and transport and the suggestion that these agents be taken with meals are not recommended.
...
1
2
3
4
...