Potentiation of endothelium-dependent relaxation by epoxyeicosatrienoic acids.

  title={Potentiation of endothelium-dependent relaxation by epoxyeicosatrienoic acids.},
  author={Neal L. Weintraub and Xiang Fang and Terry L. Kaduce and M Vanrollins and Purnima Chatterjee and Arthur A. Spector},
  journal={Circulation research},
  volume={81 2},
Epoxyeicosatrienoic acids (EETs) are potent endothelium-derived vasodilators formed from cytochrome P-450 metabolism of arachidonic acid. EETs and their diol products (DHETs) are also avidly taken up by endothelial cells and incorporated into phospholipids that participate in signal transduction. To investigate the possible functional significance of EET and DHET incorporation into cell lipids, we examined the capacity of EETs and DHETs to relax porcine coronary arterial rings and determined… CONTINUE READING