Potentiation of coronary vasoconstriction by beta-adrenergic blockade in patients with coronary artery disease.

@article{Kern1983PotentiationOC,
  title={Potentiation of coronary vasoconstriction by beta-adrenergic blockade in patients with coronary artery disease.},
  author={Morton J Kern and Peter A Ganz and John David Horowitz and Jorge Gaspar and William H. Barry and Beverly H. Lorell and William M. Grossman and Gilbert H. Mudge},
  journal={Circulation},
  year={1983},
  volume={67 6},
  pages={1178-85}
}
Although beta-adrenergic blocking agents reduce myocardial oxygen consumption and symptoms of myocardial ischemia in patients with coronary artery disease (CAD), propranolol has been reported to exacerbate coronary artery spasm in some patients with variant angina. To determine whether increased coronary vasomotor tone can be induced by beta-adrenergic blockade, we measured the changes in coronary vascular resistance (CVR) during cold pressor testing (CPT) in 15 patients, nine with severe CAD… CONTINUE READING
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Comparison of metabolic and vasoconstrictor stimuli on coronary vascular resistance in man

  • GH Mudge, S Goldberg, GuntherS, T Mann, W Grossman
  • Circulation
  • 1979

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