Potentiation of contractile response and increase in tissue sodium content induced by aconitine in the guinea-pig vas deferens.

Abstract

Aconitine potentiated the contractile response of the guinea-pig vas deferens and increased the tissue Na and Ca content. These effects were abolished in the presence of tetrodotoxin. These results suggest that aconitine causes an increasing Na+ permeability of the smooth muscle membrane to increase Ca2+ availability and thus induces potentiation. 

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Cite this paper

@article{Ohizumi1987PotentiationOC, title={Potentiation of contractile response and increase in tissue sodium content induced by aconitine in the guinea-pig vas deferens.}, author={Yuki Ohizumi and Akiharu Kajiwara}, journal={The Journal of pharmacy and pharmacology}, year={1987}, volume={39 4}, pages={324-6} }