Potentiation of combined BCNU and hyperthermia by pH reduction in vitro and hypertonic glucose in vivo in the BT4 rat glioma.

@article{Schem1989PotentiationOC,
  title={Potentiation of combined BCNU and hyperthermia by pH reduction in vitro and hypertonic glucose in vivo in the BT4 rat glioma.},
  author={B C Schem and Olav Mella and Olav Dahl},
  journal={International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group},
  year={1989},
  volume={5 6},
  pages={
          707-15
        }
}
  • B. Schem, O. Mella, O. Dahl
  • Published 1989
  • Medicine, Biology
  • International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
In vitro studies have shown enhanced cell killing of BCNU and hyperthermia at acutely lowered pH. In animals hypertonic glucose i.p. has repeatedly been demonstrated to reduce intratumoral pH. Effect of hyperthermia (43 degrees C for 45 min), or BCNU (3.33 micrograms/ml or both on BT4C cells were investigated in vitro, with pH 7.5, 7.0 and 6.5 in the medium during treatment. The effect of elevated glucose concentration in the medium (20 mmol/l) during treatment with hyperthermia, or BCNU, or… 
9 Citations
Thermal enhancement of ACNU and potentiation of thermochemotherapy with ACNU by hypertonic glucose in the BT4An rat glioma
TLDR
Glucose load represented a therapeutic gain when administered before thermochemotherapy with ACNU, presumably by lowering tumour pH through blood flow reduction, in the malignant rat glioma BT4An.
Effect of hypertonic glucose in thermotolerant rat BT4An gliomas treated with combined hyperthermia and BCNU in vivo.
  • B. Schem, O. Mella, S. Roszinski, O. Dahl
  • Medicine, Biology
    International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
  • 1996
TLDR
Glucose administered before treatment of thermotolerant tumours did not change the growth rate of tumours treated with hyperthermia, BCNU, or thermochemotherapy with a low or high dose BCnU, in contrast to previous results, where glucose enhanced thermochemosensitivity of non-thermotolerants tumours.
Thermochemotherapy with cisplatin or carboplatin in the BT4 rat glioma in vitro and in vivo.
Intravenous infusion of glucose and the vasodilator sodium nitroprusside in combination with local hyperthermia: effects on tumour pH and tumour response in the BT4An rat tumour model.
  • B. Krossnes, S. Geisler, O. Mella
  • Medicine, Biology
    International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
  • 1998
TLDR
Sodium nitroprusside induced hypotension during HT did not increase the pH fall after 1 h HT, but the pH 60 min after discontinuation of HT was lower in this group than in the HT alone group, and adding SNP to HT was found to prolong the tumour growth time slightly.
A century with hyperthermic oncology in Scandinavia.
The hyperthermic research during the last 100 years is reviewed with the aim to describe a research activity which has been performed in parallel to and associated with the development of radiation
Interaction of Heat and Drugs In Vitro and In Vivo
TLDR
The intention of this chapter is to review existing experimental data on combinations of cytotoxic drugs and hyperthermia, and attention will be drawn to findings which may form a basis for the design of clinical studies.
Thermoradiotherapy for Brain Tumors
TLDR
There has been much interest in using thermoradiotherapy in the treatment of primary brain tumors because patients treated conventionally have a poor prognosis despite a wide variety of treatment approaches and local disease progression is the predominant pattern of failure.

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