Potentiation of cocaine toxicity with calcium channel blockers.

  title={Potentiation of cocaine toxicity with calcium channel blockers.},
  author={Robert Wayne Derlet and T E Albertson},
  journal={The American journal of emergency medicine},
  volume={7 5},
Three calcium channel blockers were studied for efficacy in preventing seizures and death from cocaine intoxication. Rats were first pretreated with a test drug then subjected to high dose intraperitoneal cocaine. In this model, control animals developed seizures within six minutes, followed by death within ten minutes. Animals that were pretreated with diltiazem, nifedipine, or verapamil developed seizures significantly faster than controls, and at specific doses the death rate was higher than… CONTINUE READING