Potentiation of cisplatin activity by the bioreductive agent tirapazamine.

  title={Potentiation of cisplatin activity by the bioreductive agent tirapazamine.},
  author={Dietmar W. Siemann and Cheri A Hinchman},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  volume={47 2},
PURPOSE The chemosensitizing potential of the benzotriazine-N-oxide tirapazamine was determined in rodent mammary tumor cells grown as solid tumors. MATERIALS AND METHODS C3H/HeJ mice bearing i.m. transplanted 16C mammary carcinomas were treated with varying doses of either cisplatin alone or cisplatin in combination with a 0.27 mmol/kg dose of tirapazamine. Tumor response to single agent or combination therapy was assessed using an in situ tumor growth delay assay. Normal tissue toxicity… CONTINUE READING


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