Potentiation of central effects of L-dopa by an inhibitor of catechol-O-methyltransferase

  title={Potentiation of central effects of L-dopa by an inhibitor of catechol-O-methyltransferase},
  author={Jari Timo Juhani Nuutila and Seppo Kaakkola and Pekka T. M{\"a}nnist{\"o}},
  journal={Journal of Neural Transmission},
The effects of a COMT-inhibitor, U-0521, and a MAO-B-inhibitor, l-deprenyl, on L-dopa-induced circling behaviour were compared in 6-OHDA-lesioned rats. The actions of U-0521 and l-deprenyl on the anticataleptic effect of L-dopa were also studied. Both U-0521 and l-deprenyl were found to potentiate L-dopa-induced circling behaviour and anticataleptic effect of L-dopa. In both test systems the L-dopa potentiation of l-deprenyl was longer-lasting than that caused by U-0521. Thus inhibition of COMT… CONTINUE READING


Publications citing this paper.
Showing 1-2 of 2 extracted citations


Publications referenced by this paper.
Showing 1-10 of 20 references

Preferential deamination

A Delini-Stula, L Maitre
View 1 Excerpt

Similar Papers

Loading similar papers…