Potentiation of central effects of L-dopa by an inhibitor of catechol-O-methyltransferase

@article{Nuutila1987PotentiationOC,
  title={Potentiation of central effects of L-dopa by an inhibitor of catechol-O-methyltransferase},
  author={Jari Timo Juhani Nuutila and Seppo Kaakkola and Pekka T. M{\"a}nnist{\"o}},
  journal={Journal of Neural Transmission},
  year={1987},
  volume={70},
  pages={233-240}
}
The effects of a COMT-inhibitor, U-0521, and a MAO-B-inhibitor, l-deprenyl, on L-dopa-induced circling behaviour were compared in 6-OHDA-lesioned rats. The actions of U-0521 and l-deprenyl on the anticataleptic effect of L-dopa were also studied. Both U-0521 and l-deprenyl were found to potentiate L-dopa-induced circling behaviour and anticataleptic effect of L-dopa. In both test systems the L-dopa potentiation of l-deprenyl was longer-lasting than that caused by U-0521. Thus inhibition of COMT… CONTINUE READING

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Preferential deamination

A Delini-Stula, L Maitre
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