Potentiation of cell-mediated immune responses against recombinant HN protein of Newcastle disease virus by recombinant chicken IL-18.

@article{Su2011PotentiationOC,
  title={Potentiation of cell-mediated immune responses against recombinant HN protein of Newcastle disease virus by recombinant chicken IL-18.},
  author={Bor Sheu Su and Pin Chun Shen and Li Hsiang Hung and Ji Ping Huang and Hsien Sheng Yin and Long Huw Lee},
  journal={Veterinary immunology and immunopathology},
  year={2011},
  volume={141 3-4},
  pages={283-92}
}
In this study, recombinant fowlpox viruses (rFPV/HN) expressing Newcastle disease virus (NDV) HN protein and rFPV/HN/chIL-18 co-expressing chicken IL-18 (chIL-18) and HN protein have been constructed and characterized. The co-expressed rHN/chIL-18 antigen or rchIL-18, expressed by our previous construct rFPV/chIL-18 and co-administered with NDV rHN, was assessed for its immunostimulatory activities and protection against NDV challenge in 2-week-old chickens. Chickens were vaccinated… CONTINUE READING
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