Potentiation of acid-sensing ion channel activity by the activation of 5-HT₂ receptors in rat dorsal root ganglion neurons.

@article{Qiu2012PotentiationOA,
  title={Potentiation of acid-sensing ion channel activity by the activation of 5-HT₂ receptors in rat dorsal root ganglion neurons.},
  author={Fang Qiu and Chun-Yu Qiu and Yuqiang Liu and Dan Wu and Jiada Li and Wang-Ping Hu},
  journal={Neuropharmacology},
  year={2012},
  volume={63 3},
  pages={494-500}
}
Acid-sensing ion channels (ASICs), as key sensors for extracellular protons, are expressed in nociceptive sensory neurons and contribute to signalling pain caused by tissue acidosis. ASICs are also the subject of various factors. Here, we further provide evidence that the activity of ASICs is potentiated by the activation of 5-HT₂ receptors in rat dorsal root ganglion neurons. A specific 5-HT₂ receptor agonist, α-methyl-5-HT, dose-dependently enhanced proton-gated currents with an EC₅₀ of 0.13… CONTINUE READING

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