Potentiation of PGE(2)-mediated cAMP production during neuronal differentiation of human neuroblastoma SK-N-BE(2)C cells.

@article{Choi2001PotentiationOP,
  title={Potentiation of PGE(2)-mediated cAMP production during neuronal differentiation of human neuroblastoma SK-N-BE(2)C cells.},
  author={S-Y Choi and Bernard H. Choi and Byung Chang Suh and Hee Dong Chae and John S. Kim and Min Jae Shin and Sang Sun Kang and Manabu Negishi and Kyung Tai Kim},
  journal={Journal of neurochemistry},
  year={2001},
  volume={79 2},
  pages={
          303-10
        }
}
The prostaglandin-evoked cAMP production was studied in human neuroblastoma SK-N-BE(2)C cells during neuronal differentiation induced by all-trans retinoic acid. The incubation with 5 microM all-trans retinoic acid for 4-6 days promoted neurite outgrowth of cells. After differentiation, prostaglandin E(2) (PGE(2))-induced cAMP production was dramatically increased, whereas forskolin- and AlF-induced cAMP productions were not changed. The increase reached maximum after 4-days of incubation with… CONTINUE READING
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