Potentiation of N-methyl-D-aspartate-mediated neurotoxicity by immunostimulated murine microglia.

Abstract

Microglia have been shown to be immunostimulated by inflammatory cytokines and produce a number of toxic mediators. Here we report that immunostimulated microglia can synergistically enhance the N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity in rat cerebellar granule cells (CGC) in culture. Neurotoxicity was assessed by morphological… (More)

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