Potentiation of N-methyl-D-aspartate-mediated neurotoxicity by immunostimulated murine microglia.

@article{Kim1998PotentiationON,
  title={Potentiation of N-methyl-D-aspartate-mediated neurotoxicity by immunostimulated murine microglia.},
  author={W K Kim and Kwang Ho Ko},
  journal={Journal of neuroscience research},
  year={1998},
  volume={54 1},
  pages={17-26}
}
Microglia have been shown to be immunostimulated by inflammatory cytokines and produce a number of toxic mediators. Here we report that immunostimulated microglia can synergistically enhance the N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity in rat cerebellar granule cells (CGC) in culture. Neurotoxicity was assessed by morphological examination and by measuring the release of lactate dehydrogenase and DNA fragmentation. Cultured microglia were immunostimulated by interferon-gamma… CONTINUE READING

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